Cancer datasets and tissue pathways

The College's Datasets for Histopathological Reporting on Cancers are vital for standardising cancer reporting methods among pathologists. These datasets define the range of acceptable practice in handling pathology specimens, and enhance cancer diagnosis and treatment quality. 

Cancer datasets encompass structured collections of data related to cancer patients. Tissue pathways are instrumental in defining best practices when handling pathology specimens from patients who do not have cancer. These guidelines are pivotal in raising the bar for healthcare standards in pathology.

TNM 9 is to be implemented in most specialties for patients diagnosed on or after 1 January 2026. A full list of staging systems to be used (by specialty) is available in the Recommendations from the Recommendation on the use of tumour staging systems from the College’s Working Group on Cancer Services. See below for the full list of staging recommendations for each specialty. 

The updated TNM 9 staging appendices are now available accompanying the datasets below.

 

Webinar programme: guidance for implementation of new and revised guidelines  

The Professional Guidelines team are launching an online learning programme to further support pathologists with the implementation of new and revised clinical guidelines. Click here for more information and to book a place onto one of the upcoming webinars.

 

Bone and soft tissue

Primary bone tumours

G096 Dataset for histopathology reports on primary bone tumours

Appendix C Reporting proforma for bone tumour reports

 

Soft tissue sarcomas

Reporting proforma for soft tissue sarcomas (Appendix E)

Dataset for histopathological reporting of soft tissue sarcoma

An audit of the histopathological reporting of soft tissue sarcomas

Webinar: Implementation guidance for reporting of soft tissue sarcomas

 

Tissue pathways for bone and soft tissue pathology

G105 Tissue pathways for bone and soft tissue pathology

An audit of tissue pathways for bone and soft tissue pathology

 

 

Cancer of unknown primary and malignancy of unknown primary origin

G167 Dataset for histopathological reporting of cancer of unknown primary and malignancy of unknown primary origin

Appendix C Reporting proforma for cancer of unknown primary

Appendix E Histopathology worksheet for metastatic carcinoma of uncertain primary site.docx

An audit of histopathological reporting of CUP and MUO.docx

 

Cardiovascular system

Cardiovascular pathology

G074 Tissue pathways for cardiovascular pathology

An audit of turnaround times for the reporting of cardiovascular tissue specimens.docx

 

 

Central nervous system

Tissue pathways for non-neoplastic neuropathology specimens

G101 Tissue pathways for non-neoplastic neuropathology specimens

Webinar: Implementation guidance for non-neoplastic neuropathology specimens

An audit of quality of reporting epilepsy surgical resections for non-neoplastic lesions

An audit of quality of reporting peripheral nerve biopsies

An audit of quality of reporting muscle biopsies

An audit of quality of reporting non-neoplastic brain biopsies

An audit of quality of reporting skin biopsies for the diagnosis of small fibre neuropathy

 

 

Cytopathology

Tissue pathways for diagnostic cytopathology

G086 Tissue pathways for diagnostic cytopathology

An audit of the content and format of cytopathology reports

 

 

Endocrine system

Adult adrenal gland

January 2017 

Updated Appendix B TNM classification of adrenal cortical carcinoma

 

March 2024

Dataset for the histopathological reporting of adrenal cortical carcinoma and phaeochromocytoma/paraganglioma

Appendix D Histopathology reporting proforma for adrenal cortical carcinoma

Appendix E Histopathology reporting proforma for phaeochromocytoma and paraganglioma

An audit of reporting of ACC and phaeochromocytoma paraganglioma.docx

 

Parathyroid

G102 Dataset for the histopathological reporting of carcinomas of the parathyroid

Reporting proforma for parathyroid carcinomas (Appendix C)

An audit of histopathological reporting of carcinomas of the parathyroid

 

Thyroid

August 2023

G098 Dataset for the histopathological reporting of thyroid cancer

G098 Appendix C Reporting proforma for carcinomas of the thyroid in list format

 

 

Tissue pathways for endocrine pathology

April 2019

G078 Tissue pathways for endocrine pathology

 

 

Eye

Ocular retinoblastoma

January 2025 

G055 Dataset for histopathological reporting of ocular retinoblastoma

Appendix C Reporting proforma for ocular retinoblastoma

An audit of retinoblastoma reporting in enucleation specimens

 

Conjunctival melanoma

October 2017

Updated Appendix A TNM classification of conjunctiva melanoma and melanosis

October 2007

Dataset for the histopathological reporting of conjunctival melanoma and melanosis

Reporting proforma for conjunctival melanoma and melanosis (Appendix C)

 

Uveal melanoma

G056 Dataset for histopathological reporting of uveal melanoma

Appendix C Reporting proforma for uveal melanoma

An audit of uveal melanoma reporting in resection specimens

An audit of uveal melanoma reporting in enucleation specimens

Webinar: Implementation guidance for reporting of uveal melanoma

 

Tissue pathways for Non-neoplastic ophthalmic pathology specimens

G141 Tissue pathways for non-neoplastic ophthalmic pathology specimens

An audit of non-neoplastic ophthalmic pathology specimen reporting turnaround times

An audit on quality of reporting of non-neoplastic enucleation specimens

 

 

Gastrointestinal tract

Anal

G165 Dataset for histopathological reporting of anal cancer

Appendix C Reporting proforma for anal cancer - excisional biopsy

Appendix D Reporting proforma for anal cancer - abdominoperineal resection

Audit of anal cancer reporting in biopsy specimens.docx

 

Colorectum

HER2 in colorectal cancer - guidance for pathologists receiving requests for testing

G049 Dataset for histopathological reporting of colorectal cancer

Appendix C Reporting proforma for colorectal carcinoma resection specimens

Appendix D Reporting proforma for colorectal carcinoma local excision specimens

Appendix E Reporting proforma for further investigations for colorectal carcinoma

An audit of colorectal carcinoma reporting standards

Webinar: Implementation guidance for reporting of colorectal cancer

 

Gastrointestinal neuroendocrine tumours

G081 Dataset for histopathological reporting of neuroendocrine neoplasms of the gastrointestinal tract

Appendix C Reporting proforma for gastric neuroendocrine neoplasms resections

Appendix D Reporting proforma for duodenal:ampullary:proximal jejunal neuroendocrine neoplasms resections

Appendix E Reporting proforma for pancreatic neuroendocrine neoplasms resections

Appendix F Reporting proforma for lower jejunal and ileal neuroendocrine tumour resections

Appendix G Reporting proforma for appendiceal neuroendocrine tumour resections

Appendix H Reporting proforma for appendiceal goblet cell adenocarcinoma (previously called goblet cell carcinoid) resections

Appendix I Reporting proforma for colorectal neuroendocrine tumour resections

 

Liver

G064 Tissue pathways for liver biopsies for the investigation of medical disease and focal lesions For Publication

Updated Appendix A TNM classification of liver tumours

Webinar: Implementation guidance for liver biopsy

11 An audit of the specimen quality and reporting of medical liver biopsies

12 A clinicopathological audit of the effect of medical liver biopsies on patient management

G050 Dataset for histopathological reporting of liver resection specimens (including gallbladder) and liver biopsies for primary and metastatic carcinoma

Appendix D Reporting proforma for liver resection: hepatocellular carcinoma

Appendix E Reporting proforma for liver resection: intrahepatic cholangiocarcinoma

Appendix F Reporting proforma for liver resection: perihilar cholangiocarcinoma

Appendix G Reporting proforma for liver resection: gallbladder cancer

Appendix H Reporting proforma for liver resection: colorectal carcinoma metastasis

Webinar: Implementation guidance for reporting of liver resection specimens

An audit of reporting metastatic colorectal carcinoma in liver resection specimens

An audit of reporting primary gallbladder cancer resection specimens

An audit of reporting primary liver cancer resection specimens

 

Oesophagus

G006 Dataset for the histopathological reporting of oesophageal and gastric carcinoma

Appendix C Reporting proforma for oesophageal carcinoma resections

Appendix D Reporting proforma for gastric carcinoma resections

Appendix E Reporting proforma for gastric:oesophageal carcinoma biopsies

Appendix F Reporting proforma for gastric:oesophageal carcinoma EMR specimens

 

Pancreas, ampulla of Vater and common bile duct

G091 Dataset for the histopathological reporting of carcinomas of the pancreas, ampulla of Vater and common bile duct

Appendix E Reporting proforma for pancreatic carcinoma

Appendix F Reporting proforma for ampulla of Vater carcinoma

Appendix G Reporting proforma for common bile duct carcinoma

 

Gastrointestinal and Pancreatobiliary

G085 Tissue pathways for gastrointestinal and pancreatobiliary pathology

 

 

Gynaecological tract

Cervix

G071 Dataset for histopathological reporting of cervical neoplasia

Appendix C Reporting proforma for cervical cancer in excisional cervical biopsies

Appendix D Reporting proforma for cervical cancer in hysterectomy specimens

An audit of reports of excisional biopsy specimens for the diagnosis of cervical carcinoma

An audit of reports of hysterectomy specimen for the management of cervical carcinoma

 

Endometrium

G090 Dataset for histopathological reporting of endometrial cancer

Appendix D Reporting proforma for endometrial carcinoma excision specimens

Appendix E Reporting proforma for endometrial biopsies containing carcinoma

 

Ovary

G079 Dataset for histopathological reporting of carcinomas of the ovaries, fallopian tubes and peritoneum

Appendix D Reporting for ovarian, tubal and primary peritoneal carcinomas

Appendix E Reporting for ovarian, tubal and primary peritoneal borderline tumours

 

Uterine Sarcoma

G106 Dataset for histopathological reporting of uterine sarcomas

Appendix D Reporting proforma for cervical cancer in hysterectomy specimens

 

Vulva

G070 Dataset for histopathological reporting of vulval carcinomas

An audit of quality of reporting vulva cancer resection specimens

 

Tissue pathways for gynaecological pathology

G073 Tissue pathways for gynaecological pathology

An audit on tissue pathways for gynaecological pathology

Webinar: Implementation guidance for gynaecological pathology

 

Tissue pathway for histopathological examination of the placenta

G108 Tissue pathway for histopathological examination of the placenta

Audit of quality of reporting placental pathology

 

An audit of reporting of endometrial carcinomas on biopsy specimens

An audit of reporting of endometrial carcinomas on biopsy specimens

 

 

Head and neck

Oral cavity

G110 Dataset for the histopathological reporting of carcinomas of the oral cavity

Appendix C Reporting proforma for carcinomas of the oral cavity

An audit of quality of reporting of oral cavity resection specimens

 

Pharynx

Dataset for histopathology reporting of mucosal malignancies of the pharynx

Draft request form for node dissections (Appendix C)

Reporting proformas for head and neck datasets (Appendix D)

G189 Dataset for the histopathological reporting of carcinomas of the oropharynx and nasopharynx

Appendix C Reporting proforma for carcinomas of the oropharynx and nasopharynx

An audit of histopathology reports on carcinomas of the oropharynx and nasopharynx

Webinar: Implementation guidance for reporting carcinomas of nasopharynx and oropharynx

As the 2022 revised minimum dataset for reporting of cancers of the oropharynx and nasopharynx does not include the hypopharynx, we have also retained the old minimum dataset for reporting of cancers of the pharynx (2013) for reference.  This will be removed once the new minimum dataset for reporting of cancers of the larynx and hypopharynx is published.

Nodal excisions & neck dissection

Dataset for histopathology reporting of nodal excisions and neck dissection specimens associated with head and neck carcinomas

Draft request forms for primary mucosal carcinomas and node dissections (Appendix C)

 

We would like to inform you that while this guideline has previously undergone consultation, it will not be published in its current form. The guideline is being reviewed again following the release of the new ICCR, as it is essential to ensure it aligns with our core data requirements.

Due to the comprehensive nature of this review, which involves a complete revision and rewrite of the content, the guideline will need to go through all stages of consultation and approval again, effectively starting the process from the beginning.

We appreciate your understanding and patience as we work to deliver a high-quality, evidence-based guideline that meets the latest standards.

 

Nasal cavities & paranasal sinuses

Dataset for the histopathological reporting of carcinomas of the nasal cavity and paranasal sinuses

Appendix C Reporting proforma for carcinomas of the sinonasal tract

Appendix D Reporting proforma for carcinomas of the sinonasal tract (list format)

An audit of histopathological reporting of carcinoma of nasal cavity and paranasal sinuses

 

Salivary gland

G115-Dataset for the histopathological reporting of carcinomas of the salivary glands

Appendix C Reporting proforma for salivary gland carcinomas

Audit of quality of reporting of salivary gland cancer resection specimens.docx

 

Tissue pathways for head and neck pathology

G077 Tissue pathways for oral and head and neck pathology

An audit of quality of reporting of intraoral mucosal biopsies

An audit of reporting intraoral mucosal polypoid lesions

An audit of quality of reporting of nasal biopsies

 

Hypopharynx, larynx and trachea

G113 Dataset for the histopathological reporting of carcinomas of the hypopharynx, larynx and trachea

An audit of reporting of carcinomas of the larynx, hypopharynx and trachea

 

 

Lung and thorax

Lung cancer

G048 Dataset for histopathological reporting of lung cancer

Appendix D Reporting proforma for lung cancer resection specimens

Appendix E Reporting proforma for lung cancer biopsy/cytology specimens

 

Mesothelioma

Dataset for the histopathological reporting of mesothelioma

Reporting proforma for mesothelioma biopsy/cytology specimens (Appendix C)

Reporting proforma for mesothelioma resection specimens (Appendix D)

An audit of reporting mesotheliomas.docx

 

Thymic epithelial tumours

Dataset for the histopathological reporting of thymic epithelial tumours

Reporting proforma for resections of thymic epithelial tumours (Appendix D)

Reporting proforma for biopsy and cytology specimens of thymic epithelial tumours (Appendix E)

 

Tissue pathway for non-neoplastic thoracic pathology

Members only

G135 DRAFT Tissue pathways for non-neoplastic thoracic pathology

 

 

Lymph node and bone marrow

Lymphoma

Dataset for the histopathological reporting of lymphomas

Reporting proforma for lymphoma specimens (Appendix G)

See more

 

Tissue pathways for lymph node, spleen and bone marrow trephine biopsy specimens

Tissue pathways for lymph node, spleen and bone marrow trephine biopsy specimens

 

 

Paediatric

Renal tumours in childhood

G057 Dataset for histopathological reporting of renal tumours in childhood

An audit of renal tumours in childhood reporting in resection specimens

Reporting proforma for paediatric renal tumours (Appendix E)

Webinar: Implementation guidance for histopathological reporting of renal tumours in children

Peripheral neuroblastic tumours

Appendix I Reporting proforma for peripheral neuroblastic tumours

G104 Dataset for histopathological reporting of peripheral neuroblastic tumours

An audit of peripheral neuroblastic tumours reporting standards

 

Skin

Adnexal carcinomas and lymph nodes

Dataset for histopathological reporting of primary cutaneous adnexal carcinomas and regional lymph nodes

Appendix D1 Reporting proforma for cutaneous adnexal carcinoma removed with therapeutic intent

Appendix D2 Reporting proforma for regional lymph nodes associated with cutaneous adnexal carcinoma

 

Basal cell carcinoma

Dataset for the histopathological reporting of primary cutaneous basal cell carcinoma

Appendix D Reporting proforma for cutaneous basal cell carcinoma removed with therapeutic intent

Audit of primary cutaneous basal cell carcinoma reporting standards

 

Malignant melanoma

Dataset for histopathological reporting of primary cutaneous malignant melanoma and regional lymph nodes

Appendix D1 Reporting proforma for cutaneous malignant melanoma

Appendix D2 Reporting proforma for regional lymph nodes associated with cutaneous melanoma

Audit of primary cutaneous invasive malignant melanoma reporting standards

 

Merkel Cell carcinoma

Dataset for histopathological reporting of primary cutaneous Merkel cell carcinoma and regional lymph nodes

Appendix D1 Reporting proforma for cutaneous Merkel cell carcinoma

Appendix D2 Reporting proforma for regional lymph nodes associated with Merkel cell carcinoma

Audit of primary cutaneous invasive Merkel cell carcinoma reporting standards

 

Invasive squamous cell carcinoma

Dataset for the histopathological reporting of primary invasive cutaneous squamous cell carcinoma and regional lymph nodes

Appendix D1 Reporting proforma for cutaneous invasive squamous cell carcinoma removed with therapeutic intent

Appendix D2 Reporting proforma for regional lymph nodes associated with cutaneous invasive squamous cell carcinoma

Audit of primary cutaneous squamous cell carcinoma reporting standards

 

Tissue pathways for dermatopathology

G075 Tissue pathways for dermatopathology

An audit of turnaround times for reporting of non-neoplastic dermatopathology specimens.docx

 

Primary cutaneous lymphoma

An audit of reporting primary cutaneous lymphoma

Appendix E Reporting proforma for primary cutaneous lymphoma specimens

G190 Histopathological reporting of primary cutaneous lymphoma

 

 

Urinary tract and testis